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Research Assistant - Analytical Chemistry (m/f/d) 
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At Enamine Germany, we are building a diverse and dedicated team of chemists to support our partners from academia, the pharmaceutical industry, and the agrochemical sector through high-quality custom synthesis services.

 
The Position
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At Enamine Germany, we are growing a passionate and diverse team of chemists to support our partners from academia, biotech, pharma, and agrochemical sectors through high-quality custom synthesis and analytical services.

We are currently looking for a Research Assistant to join our analytical chemistry and preparative purification team in Frankfurt am Main. This is a hands-on laboratory role ideal for professionals who enjoy working directly with analytical and preparative systems (HPLC, LC-MS), and who are passionate about chromatography, separation science, and analytical method development.

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This Team awaits you:
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You’ll be part of an international team of around 20 colleagues at our site in Industriepark Höchst in a modern, open space laboratory. We have a motivating, collaborative work environment and support each other with theoretical knowledge and hands-on experience. Everyone’s contribution counts. 

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Your responsibilities will include: 
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  • Perform analytical testing of organic compounds using LC-MS and HPLC

  • Conduct purification of complex reaction mixtures using preparative HPLC systems

  • Develop and optimize chromatographic methods for compound isolation and characterization

  • Perform routine instrument calibration and maintenance (LC-MS, HPLC)

  • Conduct basic troubleshooting and monitor system performance

  • Collaborate closely with synthetic chemists for planning and optimization of purification strategies

  • Maintain accurate documentation in electronic lab notebooks (ELN)

  • Ensure adherence to laboratory safety and analytical quality standards

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What We’re Looking For:

You’re a great fit for this role if you’re a team-oriented lab enthusiast with an eye for detail and a drive for excellence in chromatography.

  • Completed vocational training as a chemical technician (CTA, BTA), or B.Sc. in Chemistry or related field

  • First hands-on experience with HPLC and LC-MS systems

  • Familiarity with preparative chromatography and separation optimization

  • Experience in analytical lab environments, ideally within a CRO or industry setting

  • Comfortable working with hazardous chemicals and analytical-grade solvents

  • Strong documentation, organizational, and problem-solving skills

  • Ability and interest to learn new software and instruments

  • Working knowledge of English (German is a plus)

What You Can Expect from Us:

Join a collaborative, international team of ~20 scientists at our modern facility in Industriepark Höchst.

  • Modern laboratories and state-of-the-art analytical equipment

  • A flat hierarchy with short decision-making paths and agile workflows

  • Continuous learning: training, mentoring, and knowledge exchange

  • A workplace that values safety, quality, and responsibility

  • An inclusive environment that welcomes all backgrounds and perspectives

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Note: This role is best suited for hands-on lab professionals. If your background is heavily theoretical or academic (e.g., PhD researchers), the position may not align with your expectations.

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Application Documents:

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  • Your CV

  • A motivation letter (max. one page)

  • A copy of your highest degree or vocational certificate

 
Inclusivity & Accessibility:
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We are an equal opportunity employer and value diversity at all levels. We welcome applications from all qualified individuals regardless of gender, age, background, religion, disability, or identity.

Please note that our current workplace is not fully barrier-free, but we are happy to discuss potential accessibility solutions based on your needs.

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About Enamine – Advancing Drug Discovery Together
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Founded in 1991, Enamine has grown into a leading global provider of screening compounds, building blocks, and fragment libraries, supporting early drug discovery efforts worldwide. With decades of experience and a strong foundation in medicinal and synthetic chemistry, we collaborate with pharmaceutical and biotech companies, academic institutions, and research centers to accelerate innovation in the life sciences.

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In 2023, we expanded our presence to Frankfurt am Main, establishing a dynamic site focused on:

·     FTE chemistry support

·     Custom synthesis

·     Medicinal chemistry services – including Hit-to-Lead optimization, SAR studies, and route scouting

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Our international team in Frankfurt consists of around 20 highly skilled scientists, covering diverse areas of modern synthetic chemistry. We specialize in the design and synthesis of complex small molecules, focused compound libraries, peptidomimetics, and macrocycles, combining conventional wet chemistry with innovative parallel synthesis techniques.

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At Enamine, we value scientific excellence, collaboration, and creativity. Our Frankfurt team offers a unique opportunity to work at the forefront of drug discovery in a fast-paced, collaborative, and supportive environment.

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Welcome to the world of contract research

As a CRO in the chemical industry, we operate at the intersection of science, industry, and society. Our company culture fosters an environment where scientific excellence, teamwork, and personal growth naturally go hand in hand.

What you can expect from us:

  •  Innovation meets precision: We encourage creative thinking and the use of new technologies – always with a commitment to the highest quality and scientific integrity.

  •  Teamwork: Our interdisciplinary teams collaborate closely with clients from pharma, biotech, and industry. Commitment, accountability, and open communication matter more than titles or hierarchy.

  •  Safe & agile: Even within a regulated environment, we work with agile processes, flexible structures, and short decision paths – with a clear focus on safety, compliance, and efficiency.

  • Knowledge grows with people: We care about your development. That’s why we invest in training, mentoring, and professional exchange.

  • Responsibility for people & planet: Sustainability, lab and workplace safety, and ethical conduct are not extras – they are essential to who we are.

  • Diversity drives progress: Everyone is welcome here, regardless of origin, gender, age, or background. Different perspectives make us stronger.

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